Optimal relaying in heterogeneous delay tolerant networks

In Delay Tolerant Networks (DTNs), there exists only intermittent connectivity between communication sources and destinations. In order to provide successful communication services for these challenged networks, a variety of relaying and routing algorithms have been proposed with the assumption that nodes are homogeneous in terms of contact rates and delivery costs. However, various applications of DTN have shown that mobile nodes should be divided into different classes in terms of their energy requirements and communication ability, and real application data have revealed the heterogeneous contact rates between node pairs. In this paper, we design an optimal relaying scheme for DTNs, which takes into account nodes’ heterogeneous contact rates and delivery costs when selecting relays to minimise the delivery cost while satisfying the required message delivery probability. Extensive results based on real traces demonstrate that our relaying scheme requires the least delivery cost and achieves the largest maximum delivery probability, compared with the schemes that neglect nodes’ heterogeneity

Exploiting Device-to-Device Communications to Enhance Spatial Reuse for Popular Content Downloading in Directional mmWave Small Cells

With the explosive growth of mobile demand, small cells in millimeter wave (mmWave) bands underlying the macrocell networks have attracted intense interest from both academia and industry. MmWave communications in the 60 GHz band are able to utilize the huge unlicensed bandwidth to provide multiple Gbps transmission rates. In this case, device-to-device (D2D) communications in mmWave bands should be fully exploited due to no interference with the macrocell networks and higher achievable transmission rates. In addition, due to less interference by directional transmission, multiple links including D2D links can be scheduled for concurrent transmissions (spatial reuse). With the popularity of content-based mobile applications, popular content downloading in the small cells needs to be optimized to improve network performance and enhance user experience. In this paper, we develop an efficient scheduling scheme for popular content downloading in mmWave small cells, termed PCDS (popular content downloading scheduling), where both D2D communications in close proximity and concurrent transmissions are exploited to improve transmission efficiency. In PCDS, a transmission path selection algorithm is designed to establish multi-hop transmission paths for users, aiming at better utilization of D2D communications and concurrent transmissions. After transmission path selection, a concurrent transmission scheduling algorithm is designed to maximize the spatial reuse gain. Through extensive simulations under various traffic patterns, we demonstrate PCDS achieves near-optimal performance in terms of delay and throughput, and also superior performance compared with other existing protocols, especially under heavy load.Comment: 12 pages, to appear in IEEE Transactions on Vehicular Technolog

Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells <i>in vitro</i>

A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay. The results showed that the novel compound had antiproliferative activity toward MC-38 and HT-29 cells in a dose-dependent manner. The cell cycle analysis by flow cytometry indicated that compound 6 exerted in tumor cell proliferation inhibition by arresting HT-29 cells in the G2/M phase. In addition, cell death detected by propidium iodide staining showed that compound 6 efficiently induced cell apoptosis in a concentration-dependent manner. Moreover, the sensitivity of human fibroblast cells to compound 6 was far lower than that of tumor cells, suggesting the specific anti-tumor effect of 4-thio-5-(2′′-thienyl)uridine. Taken together, novel compound 6 effectively inhibits colon cancer cell proliferation, and hence would have potential value in clinical application as an antitumor agent